EFFECT OF ADMINISTRATION OF CRUDE AQUEOUS LEAVE EXTRACT OF Anacardium occidentale ON ISOLATED RABBIT INTESTINE
DOI:
https://doi.org/10.51406/jagse.v9i1.1061Keywords:
Anacardium occidentale, intestinal motility, rabbitAbstract
The effect and probable mechanism of action of an aqueous extract of Anacardium occidentale on intestinal motility of the rabbit was studied. Five (5) rabbits were used as experimental animals in the study and the standard organ bath procedure was used to monitor and record the contractions of the isolated intestine of the rabbits. The result showed strong correlation between the log concentration of the extract and the % contractility of the ileum with r= 0.879. This correlation was highly significant at p,<0.05. Also regression analysis done on these result show y=12.236x-0.2789 and was highly significant at (p<0.05). The above result suggests that aqueous extract of Anacardium occidentale increase intestinal contraction in rabbits.
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Torihashi, S., Fujimoto, T., Troit, C., Nakayama, S. 2002. Calcium Oscillation Linked to pacemaking of Interstitial Cells of Cajal, J. Biol. F. Chem. 277:19191-19197.
Akomolafe, R.O., Adeoshun, I.O., Elujoba, A.A., Iwalewa, E.O., Ayoka A.O. 2003. Effects of Cassia sieberiena leaf extracts on the intestinal motility of rat. African Journal of Biomedical Research, 6: 141-145.
Evans, E. 2005. Hypoglycemic Potencies of Crude Ethanolic Extracts of Cashew Roots and Unripe Paw Paw Fruits in Guinea Pigs and Rats. Journal of Herbal Pharmacology, 5(1).
Guyton, A.C., Hall, J.E. Textbook of Medical Physiology (10th edition). W.B Saunders Company Philadelphia, Pp 718-726.
Ibu, J.O., Dickson, A.J., Eno, H.E. 2005. Effect of an aqueous extract of Allium sativum Linn on the intestinal motility of the Rabbit, Nigerian Journal of Health and Biomedical sciences, 4(1): 40-45.
Koh, S.D., Sanders, K.M., Ward, S.M. 1998. Spontaneous electrical rhythmcity in cultured interstitial cells of cajal from this marine snail intestine. J. Physiology, 513: 205-213.
Kuriyama, H., Kitamura, K., Itoh, T., Inoue, R. 1998. Physiological features of visceral smooth Muscle cells with special reference to receptors and ion channels. Physiol. Rev. 78: 811-920.
Leslie, T. 2005. The Healing Power of Rainforest Herbs. Raintree Nutrition, Inc. Carson City, N.
Leonard, T., Theophile, D., Paul Desire, D.D., Acha, E.A., Dongmo, S.S., Patrice, C., Jean, F.F., Pierre K. 2006. Antihyperglycemic and Renal protective activities of Anacardium occidentale in streptozotocin induced Diabetic Rats. African Journal of Traditional, complementary and Alternative Medicine 3(1): 23-35.
Mota, M.L., Thomas, G., Barbosa, F. 1985. Anti inflammatory Actions of tannins Isolated from the bark of Anacardium occidentale L. Journal of Ethnopharmacology, 13(3): 289-300.
Olajide O., Verena, M.D., Angelika, M.V., Mutallib, A.A., Aduragbemi D.A., Janet, M.M. 2004. The effects of some Nigerian plant extracts on nitric oxide production from Lipopolysaccharide-stimulated raw 264:7 macrophages.; A paper presented at the international Society of Ethnobiology – Ninth international congress at University of Kent, Canterbury U.K. 13th – 17th June, 2004.
Ojewole, J.A. 2003. Laboratory evaluation of the hypoglycemic effect of Anacardium occidentale stem bark extracts in rats. Experimental clinical pharmacology, 25(3): 199-204.
Ojewole, J.A. 2004. Potentiation of the anti inflammatory effect of Anacardium Occidentale (Linn) stem bark aqueous extract by grape fruit juice. Methods find Exp. Clin. pharmacol, 26(3): 183-8.
Torihashi, S., Fujimoto, T., Troit, C., Nakayama, S. 2002. Calcium Oscillation Linked to pacemaking of Interstitial Cells of Cajal, J. Biol. F. Chem. 277:19191-19197.
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