AMELIORATIVE EFFECTS OF ANNONA MURICATA LEAF EXTRACT ON POLYCYSTIC OVARIAN SYNDROME IN FEMALE MICE
Keywords:
Polycystic Ovary Syndrome; Soursop; letrozole; ovarian histology; blood glucose; reproductive health; endocrine disorderAbstract
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, characterized by hyperandrogenism, oligo-ovulation, and polycystic ovaries. The disorder is linked to increased risks of cardiovascular disease and non-insulin-dependent diabetes mellitus. This study evaluated the ameliorative effects of Annona muricata (Soursop) leaf extract on letrozole-induced PCOS in female mice, focusing on ovarian weight, histopathology and metabolic parameters. Twelve pubertal mice were assigned to test and control groups, with the test groups receiving letrozole (2.5 mg/kg, per os) and Annona muricata leaf extract (AMLE) 125 & 250 mg/kg by oral gavage; control groups received letrozole (2.5 mg/kg, per os) only; all were given standard feed and water ad libitum. Fasting blood glucose was measured using a glucometer, while body, ovarian and parametrial fat weights were measured using a sensitive balance. AMLE did not significantly affect ovarian weight or relative body weight gain. Fasting blood glucose levels were significantly higher in the test group compared to controls, suggesting a potential discrepancy in the anti-diabetic properties. Mild follicular degeneration in the LETAM group was observed, suggesting partial preservation of ovarian architecture and a potential protective effect of the extract. Annona muricata leaf extract may offer therapeutic benefits in mitigating ovarian damage associated with PCOS but its impact on glucose metabolism requires further investigation. There is the need for deeper exploration into dosage, treatment duration and metabolic interactions to fully understand the clinical potentials of the extract.
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