EFFICACY STUDY OF ZINC CHLORIDE AND DIMINAZENE ACETURATE ON Trypanosoma brucei INOCULATED RATS

Abstract

The   effect   of   Zinc  Chloride  (ZnCl )   and   Diminazene   aceturate  in  experimental  Trypanosoma   brucei                                          2 
       infected rats was investigated. Six groups (A-F) consisting of five rats each were used. A and F were        negative and positive controls, while B, C, D, and E were treated groups, respectively. The infection                                          6        was achieved by inoculating (1x10 ) of the parasite and rapid matching method was used to estimate        the parasitaemia in the host. Parasitaemia was monitored for 30 days using wet mount method. The        inoculated treated groups progressively showed parasitaemia five days post inoculation that caused        significant decrease (p<0.05) in packed cell volume (PCV) and white blood cell (WBC) count. After        treatment with ZnCl2  and Diminazene Aceturate (Group D), there was a remarkable improvement to-        wards the normal (Group A). This study shows that supplemental ZnCl2  could be used to alleviate the        severity of the infection in Trypanosomosis.